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What is the difference between Zantac and Prilosec?

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Prilosec and Zantac are both available over-the-counter (OTC). Prilosec is a proton pump inhibitor (PPI) that blocks the production of acid by the stomach. Zantac works differently. It is an H2 (histamine-2) blocker that inhibits the action of histamine on the cells, thus reducing the production of acid by the stomach.
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